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Allal Boutajangout's contribution to a breakthrough in Alzheimer's disease vaccine development

NYU School of Medicine researchers have prevented the development of Alzheimer's disease in mice genetically engineered with the human gene for the disease using a new vaccine. The researchers are optimistic that this new vaccine is safer than one already being tested in early human clinical trials. Genetic Mutation Linked to a More Abundant Form of Alzheimer's Protein Allal Boutajangout, PhD, Research Assistant Professor, Department of Medicine and Psychiatry at NYU Langone Medical Center NYU researchers found that a specific gene mutation previously associated with an increase in production of an Alzheimer's disease-causing protein, amyloid beta, also promotes the entanglement of another protein, tau, which also is associated with the neurodegenerative disease. Mice that produced human types of tau while expressing the gene mutation showed a significant increase in the harmful form of the tau protein in the brain. The research provides a new model for Alzheimer's onset and progression. Full story:


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